Enhancers in polymeric nonviral gene delivery systems
نویسندگان
چکیده
منابع مشابه
Structure-function correlation of chloroquine and analogues as transgene expression enhancers in nonviral gene delivery.
To understand how chloroquine (CQ) enhances transgene expression in polycation-based, nonviral gene delivery systems, a number of CQ analogues with variations in the aliphatic amino side chain or in the aromatic ring are synthesized and investigated. Our studies indicate that the aliphatic amino moiety of CQ is essential to provide increased gene expression. Further, the enhancements are more d...
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ژورنال
عنوان ژورنال: View
سال: 2020
ISSN: 2688-268X,2688-268X
DOI: 10.1002/viw.20200072